Dr. Mark R. Hofmeyer, MD, MS

Dr. Mark R. Hofmeyer, MD, MS

Dr. Mark R. Hofmeyer, MD, MS

Languages: English, German
Fax: (202) 877-9393

Contact this Provider:

  • Cardiology
  • Heart Failure and Transplantation Cardiology
Conditions I Treat
  • abnormal electrocardiogram (ekg)
  • acute decompensated heart failure
  • advanced heart failure (adhf)
  • alcoholic cardiomyopathy
  • amyloidosis
  • Show All
Procedures I Perform
  • cardiomems
  • cardiopulmonary exercise testing
  • chronic inotropic therapy
  • circulatory assist devices
  • heart biopsy
  • Show All
About the Provider

Mark Hofmeyer, MD, is Program Director of the Advanced Heart Failure and Transplant Cardiology Fellowship Program at MedStar Washington Hospital Center, Medical Director of the Advanced Heart Failure IMC, and Assistant Professor of Medicine at the Georgetown University School of Medicine. He is board certified in cardiovascular disease, advanced heart failure, and transplant cardiology. He is a member of the American College of Cardiology, the International Society of Heart and Lung Transplantation, the Heart Failure Society of America.

As an advanced heart failure cardiologist, Dr. Hofmeyer has developed a specialized and unique skill set in the care he provides for patients with advanced heart failure - the final, common pathway of all heart disease.
Dr. Hofmeyer started his career in clinical research at the University of Michigan.  After completing a master's degree, he completed his medical degree at the Wayne State University School of Medicine in Detroit.  Dr. Hofmeyer went on to Miami to complete his internship and residency training in internal medicine at the University of Miami/Jackson Memorial Hospital. He continued on at the University of Miami/Jackson Memorial Hospital to complete fellowships in cardiovascular disease and advanced heart failure and transplant cardiology.

Dr. Hofmeyer has strong clinical and research interests in the genetics of dilated cardiomyopathy.  He is a senior member of the DCM Consortium, a multisite investigator group which conducts research studies focused on thet genetics and genomics of DCM, including discovery, mechanisms of disease, genetic epidemiology, clinical genetics, and precision medicine and its related questions of behavioral and implementation science..

Dr. Hofmeyer’s practice is unique in that he partners with the palliative care team at MedStar Washington Hospital Center, offering a comprehensive approach to symptom management at all stages of disease. As part of a multidisciplinary team, Dr. Hofmeyer evaluates each individual’s diagnosis to determine the treatment plan that will best improve their overall survival and quality of life. Dr. Hofmeyer evaluates the eligibility of individuals for advanced therapies such as inotropic support, Left Ventricular Assist Devices (LVADs), or a heart transplant, and manages those patients long term.

Philosophy of Care

“I view myself as an educator as well as an advisor for each individual who comes to me for care. In order for me to provide the best care possible, it is imperative for me to understand each patient, who they are as a person, as well as their goals for treatment. 

“Advanced heart failure not only affects the individual who is diagnosed, but also their family members and their caretakers. For this reason, I get to know my patients’ loved ones so that I can understand how to support each individual as we go through this process together.

“With patience and compassion I take the time to listen to my patients and understand each person’s concerns so that I can customize a plan of care that is satisfactory to each individual patient. It is very important to me that my patient understands each treatment option that I recommend and how it relates to their underlying condition."

“I emphasize effective communication between myself and my patients. Through the development of a care plan in conjunction with my patient, my goal is for each individual to take ownership of their care and to feel empowered through this decision making process.”

  • Fellowship Program: University of Miami - Jackson Memorial Hospital (2011)
  • Fellowship Program: University of Miami - Jackson Memorial Hospital (2010)
  • Residency Program: University of Miami - Jackson Memorial Hospital (2007)
  • Medical School: Wayne State University School Of Medicine (2004)
  • Board Certification: American Board of Internal Medicine, Advanced Heart Failure and Transplant Cardiology
  • Board Certification: American Board of Internal Medicine, Cardiovascular Disease
  1. Kitahara H, Najjar S, Ahmed S, Lam P, Kadakkal A, Rodrigo M, Hofmeyer M, Sheikh F, Molina E. Edge‐to‐edge mitral repair for iatrogenic chordal rupture related to Impella 5.0. J Card Surg. 2021 Apr 14. doi: 10.1111/jocs.15517.  PMID: 33855770
  2. Grinstein J, Sawalha Y, Medvedofsky DA, Ahmad S, Hofmeyer M, Rodrigo M, Kadakkal A, Barnett C, Kalantari S, Talati I, Zaghol R, Molina EJ, Sheikh FH, Najjar SS.  VE/VCO2 slope predicts RV dysfunction and mortality after left ventricular assist device: a fresh look at cardiopulmonary stress testing for prognostication. J Artif Organs. 2021 Apr 1. doi: 10.1007/s10047-021-01261-9..J Artif Organs. 2021. PMID: 33792816  
  3. Khoury K, Lynce F, Barac A, Geng X, Dang C, Yu AF, Smith KL, Gallagher C, Pohlmann PR, Nunes R, Herbolsheimer P, Warren R, Srichai MB, Hofmeyer M, Asch F, Tan M, Isaacs C, Swain SM.  Long-term follow-up assessment of cardiac safety in SAFE-HEaRt, a clinical trial evaluating the use of HER2-targeted therapies in patients with breast cancer and compromised heart function. Breast Cancer Res Treat. 2021 Feb;185(3):863-868. doi: 10.1007/s10549-020-06053-y. Epub 2021 Jan 5.Breast Cancer Res Treat. 2021. PMID: 33400034
  4. Kenigsberg BB, Majure DT, Sheikh FH, Afari-Armah N, Rodrigo M, Hofmeyer M, Molina EJ, Wang Z, Boyce S, Najjar SS, Mohammed SF. Sex-Associated Differences in Cardiac Reverse Remodeling in Patients Supported by Contemporary Left Ventricular Assist Devices.  J Card Fail. 2020 Mar 19:S1071-9164(19)31402-2. doi: 10.1016/j.cardfail.2020.03.005
  5. Groninger H, Rao A, Stewart D, Hofmeyer M. Weaning continuous cardiac inotropes at end of life: case studies and institutional clinical guidelines. J Pain Symptom Manage. 2020 Mar 3. pii: S0885-3924(20)30123-8. doi: 10.1016/j.jpainsymman.2020.02.020.
  6. Morales A, Kinnamon DD, Jordan E, Platt J, Vatta M, Dorschner MO, Starkey CA, Mead JO, Ai T, Burke W, Gastier-Foster J, Jarvik GP, Rehm HL, Nickerson DA, Hershberger RE Variant Interpretation for Dilated Cardiomyopathy: Refinement of the American College of Medical Genetics and Genomics/ClinGen Guidelines for the DCM Precision Medicine Study.  ; DCM Precision Medicine study of the DCM Consortium; DCM Consortium institutions and personnel participating in this study: Study Principal Investigator and Co-Investigators, DCM Consortium Clinical Site Principal Investigators and Clinical Site Other Significant Contributors (OSC). Circ Genom Precis Med. 2020 Apr;13(2):e002480. doi: 10.1161/CIRCGEN.119.002480
  7. Lynce F, Barac A, Geng X, Dang C, Yu AF, Smith KL, Gallagher C, Pohlmann PR, Nunes R, Herbolsheimer P, Warren R, Srichai MB, Hofmeyer M, Cunningham A, Timothee P, Asch FM, Shajahan-Haq A, Tan MT, Isaacs C, Swain SM. Prospective evaluation of the cardiac safety of HER2-targeted therapies in patients with HER2-positive breast cancer and compromised heart function: the SAFE-HEaRt study.  Breast Cancer Res Treat. 2019 Mar 9. doi: 10.1007/s10549-019-05191-2.
  8. Brodt C, Siegfried JD, Hofmeyer M, Martel J, Rampersaud E, Li D, Norton N, Hershberger RE.  Temporal relationship of conduction system disease and ventricular dysfunction in LMNA cardiomyopathy. J Card Fail. 2013 Apr; 19(4): 233-9. doi: 10.1016/j.cardfail.2013.03.001.
  9. Morales A, Pinto J, Siegfried JD, Li D, Norton N, Hofmeyer M, Vallin M, Morales AR, Potter J, Hershberger RE. Late onset sporadic dilated cardiomyopathy caused by cardiac troponin T mutation. Clin Transl Sci. 2010 Oct; 3(5): 219-26. doi: 10.1111/j.1752-8062.2010.00228.x
  10. Li D, Morales A, Gonzalez-Quintana J, Norton N, Siegfried JD, Hofmeyer M, Hershberger RE. Identification of novel mutations in RBM20 patients with cardiomyopathy. Clin Trans Sci. 2010 Jun; 3(3): 90-7.
  11. Hofmeyer MR, Alexander NB, Nyquist LV, Medell JL, Koreishi A. Floor-rise strategy training in older adults. J Am Geriatr Soc. 2002 Oct; 50(10): 1702-6.
  12. Alexander NB, Galecki AT, Grenier ML, Nyquist LV, Hofmeyer MR, Grunawalt JC, Medell JL, Fry-Welch D.  Task-specific resistance training to improve the ability of activities of daily living-impaired older adults to rise from a bed and from a chair. J Am Geriatr Soc. 2001 Nov; 49(11): 1418-27.
  13. Alexander NB, Gross MM, Medell JL, Hofmeyer MR. Effects of functional ability and training on chair-rise biomechanics in older adults. J Gerontol A Biol Sci Med Sci. 2001 Sep; 56(9): M538-47.
  14. Alexander NB, Galecki AT, Nyquist LV, Hofmeyer MR, Grunawalt JC, Grenier ML, Medell JL.  Chair and bed rise performance in ADL-impaired congregate housing residents. J Am Geriatr Soc. 2000 May; 48(5): 526-33.
  15. Alexander NB, Galecki AT, Nyquist LV, Fry-Welch D, Hofmeyer MR, Grunawalt JC, Grenier ML, Buck JL. Predictors of Timed Chair and Bed Rise Performance. J Am Geriatr Soc 1997; 45: S38.


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Practice Locations
  • 110 Irving Street Northwest
    MedStar Heart Institute
    Washington, DC 20010
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    Phone: 202-877-2162
    Fax: 202-877-2247

  • 110 Irving Street Northwest
    MHVI-1st Floor North Addition
    Washington, DC 20010
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    Phone: 202-877-4698
    Fax: 202-877-9393

Member of Medical Staff
  • Thomas A. Curtis Outstanding Cardiovascular Fellow Award 2009-2010
  • Outstanding Resident in Ambulatory Internal Medicine 2006-2007
  • Distinction in Biomedical Research, June 2004
  • Congress-Bundestag Scholar